Tirzepatide (Mounjaro) Side Effects You Should Know

Tirzepatide (also known as Mounjaro) has become a popular treatment option for Canadians. While this medication has been proven to be effective when combined with regular exercise and a healthy diet, it's also important to be aware of its potential side effects. 

By educating yourself about Mounjaro, you can better assess the benefits and risks of using this medication. Let's explore the side effects you should know about in order to make a well-informed decision on whether this medication is a good choice for you. 

What are the Side Effects of Tirzepatide (Mounjaro)? 

Mounjaro is an injectable medication that works by activating GIP and GLP-1 receptors in the body to help improve blood sugar levels. 

Some of the most common Mounjaro side effects include:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Stomach pain
• Feeling weak or tired
• Acid reflux

Other side effects that may occur include belching, bloating of the stomach, gas (flatulence), increased heart rate or indigestion. 

Some patients have reported experiencing injection site reactions, such as pain, bruising, irritation, itching, and rash. These reactions should go away within a few days and be localized to the injection site only.

Who Should Not Take Tirzepatide (Mounjaro)?

Mounjaro cannot be used in patients with type 1 diabetes, a personal or family history of medullary thyroid carcinoma (MTC) or a personal history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). It is not known if Mounjaro can be used safely in people who have had pancreatitis and so you should discuss this with your healthcare practitioner. 

It’s also important to note that Mounjaro cannot be used in patients who are pregnant, breastfeeding, or trying to conceive. Patients who are currently using oral contraceptives (birth control pills) should let their healthcare practitioner know, as they may recommend alternative birth control methods while on Mounjaro.

While Mounjaro can be an effective medication, it's important to give your healthcare practitioner a detailed medical history so they can help find a treatment option that is safe and right for you. 

How Long Do the Side Effects of Tirzepatide (Mounjaro) Last? 

The length of time and the severity of the side effects of Mounjaro vary from person to person. Many people experience short-term side effects, like nausea, vomiting, and diarrhea for several days or weeks after starting treatment. These symptoms should resolve as your body adjusts to the medication. If your side effects last longer or become moderate, frequent, or unmanageable, message your healthcare practitioner to have the symptoms assessed. Side effects may return when the medication dose is increased.

Severe side effects require immediate in-person medical attention at your local emergency department or urgent care centre. In some cases, individuals may need to stop taking Mounjaro altogether.

Tips for Managing Side Effects

The most common side effects of Mounjaro are gastrointestinal in nature (nausea, vomiting, constipation, and acid reflux). There are a few strategies that may help to manage them:

• Eating smaller, more frequent meals
• Eating slowly
• Drinking plenty of water
• Avoiding fatty or sweet foods
• Eating blander foods like toast, crackers, or rice

Whether mild or moderate, you should speak with a healthcare practitioner if you're experiencing any side effects while taking Mounjaro (severe, significant or persistent side effects require immediate in-person care). They can guide you through how to manage your symptoms, how long they may last, and help ensure your overall health and well-being. 

This information does not replace medical advice. Any questions you have about your treatment are best discussed directly with your healthcare practitioner.

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